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1

10.1038/46829

Long, Paul F., Bisang, Christian, Corte´s, Jesús, Westcott, James, Crosby, John, Matharu, Anne-Lise, Cox, Russell J., Simpson, Thomas J., Staunton, James, Leadlay, Peter F.

Journal:

Year:

1999

Language:

english

File:

PDF, 196 KB

english, 1999

2

Online Curves

Staunton, Peter F., Baker, Joseph F., Green, James, Devitt, Aiden

Journal:

Year:

2015

Language:

english

File:

PDF, 1.04 MB

english, 2015

3

The Oxford Handbook of Career Development || The Role of Digital Technology in Career Development

Robertson, Peter J., Hooley, Tristram, McCash, Phil, Hooley, Tristram, Staunton, Tom

File:

PDF, 915 KB

4

Structural elucidation studies of erythromycins by electrospray tandem mass spectrometry

Paul J. Gates, Gordon C. Kearney, Raymond Jones, Peter F. Leadlay, James Staunton

Journal:

Rapid Communications in Mass Spectrometry

Year:

1999

Language:

english

File:

PDF, 66 KB

english, 1999

5

Structural elucidation studies of erythromycins by electrospray tandem mass spectrometry II

Gordon C. Kearney, Paul J. Gates, Peter F. Leadlay, James Staunton, Raymond Jones

Journal:

Rapid Communications in Mass Spectrometry

Year:

1999

Language:

english

File:

PDF, 117 KB

english, 1999

6

Structural elucidation studies of polyketide tetrasubstituted δ-lactones by gas chromatography/tandem mass spectrometry and electrospray mass spectrometry

Kira J. Weissman, Gordon C. Kearney, Peter F. Leadlay, James Staunton

Journal:

Rapid Communications in Mass Spectrometry

Year:

1999

Language:

english

File:

PDF, 115 KB

english, 1999

7

Die Thioesterase der Polyketid-Synthase von Erythromycin: Einfluß der Acylkettenstruktur auf den Abkopplungsmechanismus der Substratanaloga von der Acyl-Enzym-Zwischenstufe

Kira J. Weissman, Cameron J. Smith, Ulf Hanefeld, Ranjana Aggarwal, Matthew Bycroft, James Staunton, Peter F. Leadlay

Journal:

Angewandte Chemie

Year:

1998

Language:

german

File:

PDF, 100 KB

german, 1998

8

The Thioesterase of the Erythromycin-Producing Polyketide Synthase: Influence of Acyl Chain Structure on the Mode of Release of Substrate Analogues from the Acyl Enzyme Intermediates

Kira J. Weissman, Cameron J. Smith, Ulf Hanefeld, Ranjana Aggarwal, Matthew Bycroft, James Staunton, Peter F. Leadlay

Journal:

Angewandte Chemie International Edition

Year:

1998

Language:

english

File:

PDF, 95 KB

english, 1998

9

Origin and True Nature of the Starter Unit for the Rapamycin Polyketide Synthase

Philip A. S. Lowden, Barrie Wilkinson, Günter A. Böhm, Sandeep Handa, Heinz G. Floss, Peter F. Leadlay, James Staunton

Journal:

Angewandte Chemie

Year:

2001

Language:

english

File:

PDF, 76 KB

english, 2001

10

Origin and True Nature of the Starter Unit for the Rapamycin Polyketide Synthase

Philip A. S. Lowden, Barrie Wilkinson, Günter A. Böhm, Sandeep Handa, Heinz G. Floss, Peter F. Leadlay, James Staunton

Journal:

Angewandte Chemie International Edition

Year:

2001

Language:

english

File:

PDF, 75 KB

english, 2001

11

Die Startereinheit der Rapamycin-Polyketid-Synthase

Philip A. S. Lowden, Dr. Günter A. Böhm, Dr. James Staunton, Dr. Peter F. Leadlay

Journal:

Angewandte Chemie

Year:

1996

Language:

german

File:

PDF, 344 KB

german, 1996

12

Intermediates Released from a Polyether-Producing Polyketide Synthase Provide Insight into the Mechanism of Oxidative Cyclization

Zoë A. Hughes-Thomas, Christian B. W. Stark, Ines U. Böhm, James Staunton, Peter F. Leadlay

Journal:

Angewandte Chemie

Year:

2003

Language:

english

File:

PDF, 164 KB

english, 2003

13

Structure of the Poly(ethylene oxide)–Zinc Chloride Complex

Edward Staunton, Alasdair M. Christie, Isabelle Martin-Litas, Yuri G. Andreev, Alexandra M. Z. Slawin, Peter G. Bruce

Journal:

Angewandte Chemie

Year:

2004

Language:

english

File:

PDF, 105 KB

english, 2004

14

Isolation and Characterization of Pre-rapamycin, the First Macrocyclic Intermediate in the Biosynthesis of the Immunosuppressant Rapamycin by S. hygroscopicus

Matthew A. Gregory, Sabine Gaisser, Rachel E. Lill, Hui Hong, Rose M. Sheridan, Barrie Wilkinson, Hrvoje Petkovic, Alison J. Weston, Isabelle Carletti, Huai-Lo Lee, James Staunton, Peter F. Leadlay

Journal:

Angewandte Chemie

Year:

2004

Language:

english

File:

PDF, 106 KB

english, 2004

15

Accumulation of an E,E,E-Triene by the Monensin-Producing Polyketide Synthase when Oxidative Cyclization is Blocked

Apoorva Bhatt, Christian B. W. Stark, Barbara M. Harvey, Andrew R. Gallimore, Yuliya A. Demydchuk, Jonathan B. Spencer, James Staunton, Peter F. Leadlay

Journal:

Angewandte Chemie

Year:

2005

Language:

english

File:

PDF, 119 KB

english, 2005

16

The Nature of the Starter Unit for the Rapamycin Polyketide Synthase

Philip A. S. Lowden, Dr. Günter A. Böhm, Dr. James Staunton, Dr. Peter F. Leadlay

Journal:

Angewandte Chemie International Edition

Year:

1996

Language:

english

File:

PDF, 312 KB

english, 1996

17

Intermediates Released from a Polyether-Producing Polyketide Synthase Provide Insight into the Mechanism of Oxidative Cyclization

Zoë A. Hughes-Thomas, Christian B. W. Stark, Ines U. Böhm, James Staunton, Peter F. Leadlay

Journal:

Angewandte Chemie International Edition

Year:

2003

Language:

english

File:

PDF, 165 KB

english, 2003

18

Structure of the Poly(ethylene oxide)–Zinc Chloride Complex

Edward Staunton, Alasdair M. Christie, Isabelle Martin-Litas, Yuri G. Andreev, Alexandra M. Z. Slawin, Peter G. Bruce

Journal:

Angewandte Chemie International Edition

Year:

2004

Language:

english

File:

PDF, 105 KB

english, 2004

19

Isolation and Characterization of Pre-rapamycin, the First Macrocyclic Intermediate in the Biosynthesis of the Immunosuppressant Rapamycin by S. hygroscopicus

Matthew A. Gregory, Sabine Gaisser, Rachel E. Lill, Hui Hong, Rose M. Sheridan, Barrie Wilkinson, Hrvoje Petkovic, Alison J. Weston, Isabelle Carletti, Huai-Lo Lee, James Staunton, Peter F. Leadlay

Journal:

Angewandte Chemie International Edition

Year:

2004

Language:

english

File:

PDF, 107 KB

english, 2004

20

Accumulation of an E,E,E-Triene by the Monensin-Producing Polyketide Synthase when Oxidative Cyclization is Blocked

Apoorva Bhatt, Christian B. W. Stark, Barbara M. Harvey, Andrew R. Gallimore, Yuliya A. Demydchuk, Jonathan B. Spencer, James Staunton, Peter F. Leadlay

Journal:

Angewandte Chemie International Edition

Year:

2005

Language:

english

File:

PDF, 120 KB

english, 2005

21

Catalytically Active Tetramodular 6-Deoxyerythonolide B Synthase Fusion Proteins

Corinne M. Squire, Rebecca J. M. Goss, Hui Hong, Peter F. Leadlay, James Staunton

Journal:

Year:

2003

Language:

english

File:

PDF, 174 KB

english, 2003

22

New Rapamycin Derivatives by Precursor-Directed Biosynthesis

Philip A. S. Lowden, Günter A. Böhm, Su Metcalfe, James Staunton, Peter F. Leadlay

Journal:

Year:

2004

Language:

english

File:

PDF, 110 KB

english, 2004

23

Evidence that a Novel Thioesterase is Responsible for Polyketide Chain Release during Biosynthesis of the Polyether Ionophore Monensin

Barbara M. Harvey, Hui Hong, Michelle A. Jones, Zoë A. Hughes-Thomas, Rebecca M. Goss, Michelle L. Heathcote, Victor M. Bolanos-Garcia, Wolfgang Kroutil, James Staunton, Peter F. Leadlay, Jonathan B.

Journal:

Year:

2006

Language:

english

File:

PDF, 353 KB

english, 2006

24

Analysis of the Tetronomycin Gene Cluster: Insights into the Biosynthesis of a Polyether Tetronate Antibiotic

Yuliya Demydchuk, Yuhui Sun, Hui Hong, James Staunton, Jonathan B. Spencer, Peter F. Leadlay

Journal:

Year:

2008

Language:

english

File:

PDF, 814 KB

english, 2008

25

A Polylinker Approach to Reductive Loop Swaps in Modular Polyketide Synthases

Laurenz Kellenberger, Ian S. Galloway, Guido Sauter, Günter Böhm, Ulf Hanefeld, Jesús Cortés, James Staunton, Peter F. Leadlay

Journal:

Year:

2008

Language:

english

File:

PDF, 412 KB

english, 2008

26

ChemInform Abstract: Enantiospecific Synthesis of Tetrasubstituted δ-Lactones.

Annabel L. Wilkinson, Ulf Hanefeld, Barrie Wilkinson, Peter F. Leadlay, James Staunton

Journal:

Year:

1999

File:

PDF, 30 KB

1999

27

ChemInform Abstract: Novel Erythromycins from a Recombinant Saccharopolyspora erythraea Strain NRRL 2338 pIG1. Part 1. Fermentation, Isolation, and Biological Activity.

Michael S. Pacey, John P. Dirlam, Roderick W. Geldart, Peter F. Leadlay, Hamish A. I. McArthur, Ellen L. McCormick, Robert A. Monday, Thomas N. O'Connell, James Staunton, Toby J. Winchester

Journal:

Year:

1999

File:

PDF, 30 KB

1999

28

A Novel Erythromycin, 6-Desmethyl Erythromycin D, Made by Substituting an Acyltransferase Domain of the Erythromycin Polyketide Synthase.

Hrvoje Petkovic, Rachel E. Lill, Rose M. Sheridan, Barrie Wilkinson, Ellen L. McCormick, Hamish A. I. McArthur, James Staunton, Peter F. Leadlay, Steven G. Kendrew

Journal:

Year:

2003

File:

PDF, 70 KB

2003

29

Biosynthesis of tetronasin: Part 5. Novel fluorinated and non-fluorinated analogues of tetronasin via intact incorporation of di-, tri- and tetraketide analogue precursors

Simon L. Less, Sandeep Handa, Peter F. Leadlay, Christopher J. Dutton, James Staunton

Journal:

Tetrahedron Letters

Year:

1996

Language:

english

File:

PDF, 269 KB

english, 1996

30

Biosynthesis of tetronasin: Part 7. Preparation of structural analogues of the tetraketide biosynthetic precursor to tetronasin

Simon L. Less, Peter F. Leadlay, Christopher J. Dutton, James Staunton

Journal:

Tetrahedron Letters

Year:

1996

Language:

english

File:

PDF, 134 KB

english, 1996

31

Biosynthesis of tetronasin: Part 6. Preparation of structural analogues of the diketide and triketide biosynthetic precursors to tetronasin

Simon L. Less, Sandeep Handa, Karen Millburn, Peter F. Leadlay, Christopher J. Dutton, James Staunton

Journal:

Tetrahedron Letters

Year:

1996

Language:

english

File:

PDF, 238 KB

english, 1996

32

Stereospecificity in the biosynthesis of papaverine

Alan R. Battersby, Peter W. Sheldrake, James Staunton, Michael C. Summers

Journal:

Bioorganic Chemistry

Year:

1977

Language:

english

File:

PDF, 226 KB

english, 1977

33

Polyketide synthesis in vitro on a modular polyketide synthase

Kirsten E.H. Wiesmann, Jesus Cortés, Murray J.B. Brown, Annabel L. Cutter, James Staunton, Peter F. Leadlay

Journal:

Chemistry & Biology

Year:

1995

Language:

english

File:

PDF, 1.65 MB

english, 1995

34

Molecular Basis of Celmer's Rules: Stereochemistry of Catalysis by Isolated Ketoreductase Domains from Modular Polyketide Synthases

Alexandros P. Siskos, Abel Baerga-Ortiz, Shilpa Bali, Viktor Stein, Hassan Mamdani, Dieter Spiteller, Bojana Popovic, Jonathan B. Spencer, James Staunton, Kira J. Weissman, Peter F. Leadlay

Journal:

Chemistry & Biology

Year:

2005

Language:

english

File:

PDF, 205 KB

english, 2005

35

Evidence for the Role of the monB Genes in Polyether Ring Formation during Monensin Biosynthesis

Andrew R. Gallimore, Christian B.W. Stark, Apoorva Bhatt, Barbara M. Harvey, Yuliya Demydchuk, Victor Bolanos-Garcia, Daniel J. Fowler, James Staunton, Peter F. Leadlay, Jonathan B. Spencer

Journal:

Chemistry & Biology

Year:

2006

Language:

english

File:

PDF, 357 KB

english, 2006

36

Avermectin biosynthesis. Intact incorporation of a diketide chain-assembly intermediate into the polyketide macrocyclic ring

Christopher J. Dutton, Antony M. Hooper, Peter F. Leadlay, James Staunton

Journal:

Tetrahedron Letters

Year:

1994

Language:

english

File:

PDF, 373 KB

english, 1994

37

Biosynthesis of tetronasin: Part 1 introduction and investigation of the diketide and triketide intermediates bound to the polyketide synthase

Helen C. Hailes, Catherine M. Jackson, Peter F. Leadlay, Steven V. Ley, James Staunton

Journal:

Tetrahedron Letters

Year:

1994

Language:

english

File:

PDF, 393 KB

english, 1994

38

Biosynthesis of tetronasin: Part 3 preparation of deuterium labelled tri- and tetraketides as putative biosynthetic precursors of tetronasin

Helen C. Hailes, Sandeep Handa, Peter F. Leadlay, Ian C. Lennon, Steven V. Ley, James Staunton

Journal:

Tetrahedron Letters

Year:

1994

Language:

english

File:

PDF, 296 KB

english, 1994

39

Biosynthesis of tetronasin: Part 2 identification of the tetraketide intermediate attached to the polyketide synthase

Helen C. Hailes, Sandeep Handa, Peter F. Leadlay, Ian C. Lennon, Steven V. Ley, James Staunton

Journal:

Tetrahedron Letters

Year:

1994

Language:

english

File:

PDF, 402 KB

english, 1994

40

Enantiospecific synthesis of tetrasubstituted δ-lactones

Annabel L. Wilkinson (née Cutter), Ulf Hanefeld, Barrie Wilkinson, Peter F. Leadlay, James Staunton

Journal:

Tetrahedron Letters

Year:

1998

Language:

english

File:

PDF, 263 KB

english, 1998

41

Knowledge-based design of bimodular and trimodular polyketide synthases based on domain and module swaps: a route to simple statin analogues

Anand Ranganathan, Máire Timoney, Matthew Bycroft, Jesús Cortés, Iain P Thomas, Barrie Wilkinson, Laurenz Kellenberger, Ulf Hanefeld, Ian S Galloway, James Staunton, Peter F Leadlay

Journal:

Chemistry & Biology

Year:

1999

Language:

english

File:

PDF, 145 KB

english, 1999

42

Role of type II thioesterases: evidence for removal of short acyl chains produced by aberrant decarboxylation of chain extender units

Michelle L Heathcote, James Staunton, Peter F Leadlay

Journal:

Chemistry & Biology

Year:

2001

Language:

english

File:

PDF, 870 KB

english, 2001

43

Molecular basis of Celmer’s rules: role of the ketosynthase domain in epimerisation and demonstration that ketoreductase domains can have altered product specificity with unnatural substrates

Ines E Holzbaur, Anand Ranganathan, Iain P Thomas, Dominic J.A Kearney, James A Reather, Brian A.M Rudd, James Staunton, Peter F Leadlay

Journal:

Chemistry & Biology

Year:

2001

Language:

english

File:

PDF, 838 KB

english, 2001

44

Engineering a polyketide with a longer chain by insertion of an extra module into the erythromycin-producing polyketide synthase

Christine J Rowe, Ines U Böhm, Iain P Thomas, Barrie Wilkinson, Brian A.M Rudd, Graham Foster, Andrew P Blackaby, Philip J Sidebottom, Ylva Roddis, Anthony D Buss, James Staunton, Peter F Leadlay

Journal:

Chemistry & Biology

Year:

2001

Language:

english

File:

PDF, 1.21 MB

english, 2001

45

Chain initiation on the soraphen-producing modular polyketide synthase from Sorangium cellulosum

Christopher J Wilkinson, Elizabeth J Frost, James Staunton, Peter F Leadlay

Journal:

Chemistry & Biology

Year:

2001

Language:

english

File:

PDF, 773 KB

english, 2001

46

Skipping in a Hybrid Polyketide Synthase: Evidence for ACP-to-ACP Chain Transfer

Iain Thomas, Christine J Martin, Christopher J Wilkinson, James Staunton, Peter F Leadlay

Journal:

Chemistry & Biology

Year:

2002

Language:

english

File:

PDF, 239 KB

english, 2002

47

A hybrid modular polyketide synthase obtained by domain swapping

Markiyan Oliynyk, Murray J.B. Brown, Jesús Cortés, James Staunton, Peter F. Leadlay

Journal:

Chemistry & Biology

Year:

1996

Language:

english

File:

PDF, 2.35 MB

english, 1996

48

Engineering of a minimal modular polyketide synthase, and targeted alteration of the stereospecificity of polyketide chain extension

Ines Böhm, Inès E. Holzbaur, Ulf Hanefeld, Jesus Cortési, Jim Staunton, Peter F. Leadlay

Journal:

Chemistry & Biology

Year:

1998

Language:

english

File:

PDF, 1.19 MB

english, 1998

49

Evaluating precursor-directed biosynthesis towards novel erythromycins through in vitro studies on a bimodular polyketide synthase

Kira J. Weissman, Matthew Bycroft, Annabel L. Cutter, Ulf Hanefeld, Elizabeth J. Frost, Máire C. Timoney, Rebecca Harris, Sandeep Handa, Marc Roddis, James Staunton, Peter F. Leadlay

Journal:

Chemistry & Biology

Year:

1998

Language:

english

File:

PDF, 2.61 MB

english, 1998

50

Molecular basis of celmer's rules: the role of two ketoreductase domains in the control of chirality by the erythromycin modular polyketide synthase

Inès E Holzbaur, Rebecca C Harris, Matthew Bycroft, Jesus Cortes, Christian Bisang, James Staunton, Brian A.M. Rudd, Peter F Leadlay

Journal:

Chemistry & Biology

Year:

1999

Language:

english

File:

PDF, 916 KB

english, 1999

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